Contraindicated. CYP3A4 is accountable for the development and elimination of cariprazine's active metabolites. The outcome of CYP3A4 inducers on cariprazine exposure has not been evaluated as well as the Web result is unclear.pentobarbital will lessen the extent or effect of fosaprepitant by affecting hepatic/intestinal enzyme CYP3A4 metabolism. U
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